“The mission of Mind Body Health & Politics is to expand consciousness, stimulate thought, enhance mental and physical health, and encourage community.” — Dr. Richard L. Miller
I am thrilled to share with you my recent interview with Dr. Kelan Thomas, a renowned psychiatric pharmacist and psychopharmacology researcher. Dr. Thomas holds a PharmD, MS, and BCPP, and is dedicated to improving mental health care through clinical pharmacy and research.
In this episode, we continue to cast a bright light on the adverse effects of psychedelics, and in particular, concerns around the potential heart risks associated with chronic microdosing of the classic serotonergic psychedelics such as LSD and psilocybin. Dr. Thomas shared insights into the binding affinities of psychedelic compounds and their effects on serotonin receptors, specifically the 5-HT2B receptor.
“My primary concern is how many people have been continuously microdosing for three months, six months, or even a year without taking any breaks,” he says.
He believes that microdosing twice-weekly for several months, for example, can lead to valvular heart disease. This is a known side effect of a whole class of drugs with high binding affinity at the 2B receptor. According to FDA regulatory reviews, about one in four people develop this issue while taking these drugs.
“However,” he notes, “this hasn't been specifically shown with LSD microdosing; it's an extrapolation from other substances.”
Those of us who were around in the 1960s remember the campaigns that demonized LSD. The media and government conspired to spread misinformation, falsely linking LSD with chromosomal breaks and making other fictitious claims. We must be cautious not to blindly believe every finding, but we should also remain open to the possibility of the unknown unknowns.
Fortunately, we are now emerging from the era of suppression of research. Studies can now be conducted on individuals who are actively engaged in microdosing, enabling more accurate data collection. If you are currently microdosing, considering it, or know someone who is, be sure to share this important broadcast, along with the links to Dr. Thomas's work below.
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